“The mantra Om Mani Päme Hum is easy to say yet quite powerful, because it contains the essence of the entire teaching. When you say the first syllable Om it is blessed to help you achieve perfection in the practice of generosity, Ma helps perfect the practice of pure ethics, and Ni helps achieve perfection in the practice of tolerance and patience. Pä, the fourth syllable, helps to achieve perfection of perseverance, Me helps achieve perfection in the practice of concentration, and the final sixth syllable Hum helps achieve perfection in the practice of wisdom. So in this way recitation of the mantra helps achieve perfection in the six practices from generosity to wisdom. The path of these six perfections is the path walked by all the Buddhas of the three times. What could then be more meaningful than to say the mantra and accomplish the six perfections?”

— Dilgo Khyentse Rinpoche, Heart Treasure of the Enlightened Ones

“It is very good to recite the mantra Om mani padme hum, but while you are doing it, you should be thinking on its meaning, for the meaning of the six syllables is great and vast …. The first, OM … symbolizes the practitioner’s impure body, speech, and mind; it also symbolizes the pure exalted body, speech, and mind of a Buddha…. The path is indicated by the next four syllables. MANI, meaning jewel, symbolizes the … altruistic intention to become enlightened, compassionate and loving…. The two syllables, PADME, meaning lotus, symbolize wisdom…. Purity must be achieved by an indivisible unity of method and wisdom, symbolized by the final syllable HUM, which indicates indivisibility…. Thus the six syllables, om mani padme hum, mean that in dependence on the practice of a path which is an indivisible union of method and wisdom, you can transform your impure body, speech, and mind into the pure exalted body, speech, and mind of a Buddha….”

— His Holiness the Dalai Lama

When you say “Om”, you are making the sound that represents purity. Purity of body, mind and speech.

You then say “Mani Padme Hum”. And these words represent the path.

Mani means love and compassion.

Padme means the lotus and represents wisdom

Hum means enlightenment.

Put it together and you get: “Purity of mind, body and speech. Path. Love and compassion. Wisdom. Enlightenment.”

Translate this and it reads, “Be pure in body mind and speech. Follow the path of wisdom with love and compassion. Buddhahood will result”.